CELF2 antibody (N-Term)

Catalog No. ABIN2779001

Cited in 1 publication. The Rabbit Polyclonal anti-CELF2 antibody (ABIN2779001) specifically detects CELF2 in WB and IHC. The antibody is reactive with Human and Cow samples.

Quick Overview for CELF2 antibody (N-Term) (ABIN2779001)

Target: CELF2 (CUGBP, Elav-Like Family Member 2 (CELF2))

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CELF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CELF2 Antibody

Binding Specificity: N-Term

Sequence: TSAFKLDFLP DMMVEGRLLV PDRINGTANK MNGALDHSDQ PDPDAIKMFV

Predicted Reactivity: Cow: 100%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CUGBP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CUGBP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 521 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CELF2 antibody (ABIN2779001)

Subramaniam, Natarajan, Ramalingam, Ramachandran, May, Queimado, Houchen, Anant: "Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 4, pp. G1025-32, (2008) (PubMed).

Target Details for CELF2

Target: CELF2 (CUGBP, Elav-Like Family Member 2 (CELF2))

Alternative Name: CUGBP2

Background: CUGBP2 is a member of the CELF/BRUNOL protein family, which contains two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of CUGBP2 family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. If alternative splicing were to result, multiple transcript variants encoding different isoforms would appear.Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: BRUNOL3, ETR-3, NAPOR, ETR3, CUGBP2
Protein Interaction Partner: PTGS2, ELAVL1, UBC, FN1, APP, PCBP1, A1CF, APOBEC1, Apob,
Protein Size: 521

Molecular Weight: 56 kDa

Gene ID: 10659

NCBI Accession: NM_006561, NP_006552

Pathways: Ribonucleoprotein Complex Subunit Organization