EIF2D antibody (Middle Region)

Catalog No. ABIN2779012

This Rabbit Polyclonal antibody specifically detects EIF2D in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Guinea Pig, Pig and Rabbit.

Quick Overview for EIF2D antibody (Middle Region) (ABIN2779012)

Target: EIF2D (Eukaryotic Translation Initiation Factor 2D (EIF2D))

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EIF2D Antibody

Binding Specificity: Middle Region

Purpose: LGTN Antibody - middle region

Sequence: KVTVVRNLEA YGLDPYSVAA ILQQRCQAST TVNPAPGAKD SLQVQIQGNQ

Predicted Reactivity: Dog: 93%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against LGTN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LGTN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40690-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for EIF2D

Target: EIF2D (Eukaryotic Translation Initiation Factor 2D (EIF2D))

Alternative Name: LGTN

Background:

Background Information: LGTN is a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.

Gene Name: Eukaryotic translation initiation factor 2D

Alternative Symbols: LGTN, HCA56

Protein Name: Eukaryotic translation initiation factor 2D

Molecular Weight: 65kDa

Gene ID: 1939

NCBI Accession: NP_008824

UniProt: P41214