IRAK3 antibody (C-Term)

Catalog No. ABIN2779025

The Rabbit Polyclonal anti-IRAK3 antibody has been validated for WB. It is suitable to detect IRAK3 in samples from Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Dog.

Quick Overview for IRAK3 antibody (C-Term) (ABIN2779025)

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRAK3 Antibody

Binding Specificity: C-Term

Sequence: NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE DDESQNNNLL

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against IRAK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IRAK3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 596 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IRAK3

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Alternative Name: IRAK3

Background: IRAK3 contains 1 protein kinase domain and 1 death domain and belongs to the Ser/Thr protein kinase family, Pelle subfamily. It inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Alias Symbols: ASRT5, IRAKM
Protein Interaction Partner: CDCA5, NSA2, LDB1, NTRK3, NONO, HSP90AA1, HOXB7, FOLR1, ECM1, COPB1, CD14, ATP6V0B, ADH1B, IRAK1, UBC, IRAK4, IRAK2, TICAM2, IRAK3, TRAF6, MYD88,
Protein Size: 596

Molecular Weight: 66 kDa

Gene ID: 11213

NCBI Accession: NM_007199, NP_009130

UniProt: Q9Y616

Pathways: TLR Signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades