OAS2 antibody (N-Term)

Catalog No. ABIN2779106

The Rabbit Polyclonal anti-OAS2 antibody is suitable to detect OAS2 in samples from Human, Rat, Pig, Rabbit, Dog, Cow and Horse. It has been validated for WB.

Quick Overview for OAS2 antibody (N-Term) (ABIN2779106)

Target: OAS2 (2'-5' Oligoadenylate Synthetase 2 (OAS2))

Reactivity: Human, Rat, Pig, Rabbit, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OAS2 Antibody

Binding Specificity: N-Term

Purpose: OAS2 Antibody - N-terminal region

Sequence: DEMVNTICDV LQEPEQFPLV QGVAIGGSYG RKTVLRGNSD GTLVLFFSDL

Predicted Reactivity: Cow: 92%, Dog: 100%, Horse: 100%, Human: 100%, Pig: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against OAS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human OAS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40851-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for OAS2

Target: OAS2 (2'-5' Oligoadenylate Synthetase 2 (OAS2))

Alternative Name: OAS2

Background:

Background Information: OAS2 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene Name: 2'-5'-oligoadenylate synthetase 2, 69/71 kDa

Alternative Symbols: MGC78578

Protein Name: 2'-5'-oligoadenylate synthase 2

Molecular Weight: 79kDa

Gene ID: 4939

NCBI Accession: NP_002526

UniProt: P29728

Pathways: Hepatitis C