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RNP antibody (Middle Region)

RNPC3 Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Saccharomyces cerevisiae, Cow, Dog WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2779114
  • Target See all RNP (RNPC3) Antibodies
    RNP (RNPC3) (RNA-Binding Region (RNP1, RRM) Containing 3 (RNPC3))
    Binding Specificity
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Horse, Pig, Rabbit, Saccharomyces cerevisiae, Cow, Dog
    Host
    • 12
    • 3
    • 2
    Rabbit
    Clonality
    • 15
    • 2
    Polyclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNP antibody is un-conjugated
    Application
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    LHAPLPPTSP QPPEEPPLPD EDEELSSEES EYESTDDEDR QRMNKLMELA
    Predicted Reactivity
    Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 92%, Rat: 85%, Yeast: 77%
    Characteristics
    This is a rabbit polyclonal antibody against RNPC3. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human RNPC3
    Top Product
    Discover our top product RNPC3 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 517 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    RNP (RNPC3) (RNA-Binding Region (RNP1, RRM) Containing 3 (RNPC3))
    Alternative Name
    RNPC3 (RNPC3 Products)
    Synonyms
    rnp antibody, rbm40 antibody, zgc:136847 antibody, RBM40 antibody, RNP antibody, SNRNP65 antibody, 2810441O16Rik antibody, AI447568 antibody, C030014B17Rik antibody, RNA binding region (RNP1, RRM) containing 3 antibody, RNA-binding region (RNP1, RRM) containing 3 antibody, RNPC3 antibody, rnpc3 antibody, Rnpc3 antibody
    Background
    RNPC3 is an RNA-binding protein involved in pre-mRNA splicing. RNPC3 participates in pre-mRNA U12-dependent splicing. RNPC3 binds to the 3'-stem-loop of m7G-capped U12 snRNA.Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99 % of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs), suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome.
    Alias Symbols: FLJ20008, FLJ25070, KIAA183, RBM40, RNP
    Protein Interaction Partner: SMAD2, CPSF1, CDK19, RPS3A, APP, PRNP, RNU11, RNU12-2P,
    Protein Size: 517
    Molecular Weight
    58 kDa
    Gene ID
    55599
    NCBI Accession
    NM_017619, NP_060089
    UniProt
    Q96LT9
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