Crk antibody (C-Term)

Catalog No. ABIN2779332

This Rabbit Polyclonal antibody specifically detects Crk in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Guinea Pig and Horse.

Quick Overview for Crk antibody (C-Term) (ABIN2779332)

Target: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Crk antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Crk Antibody

Binding Specificity: C-Term

Sequence: IPVPYVEKYR PASASVSALI GGNQEGSHPQ PLGGPEPGPY AQPSVNTPLP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CRK. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 304 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Crk

Target: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Alternative Name: CRK

Background: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Alias Symbols: CRKII, p38
Protein Interaction Partner: FAM154A, HUWE1, ABL2, ABL1, SPRR2A, MET, CBL, BAG3, LMNA, ERBB3, ERBB2, EGFR, PPFIBP2, ATXN1, PTPN4, MAPK4, DOK1, BCAR1, NANS, FUBP1, SPR, HSPB1, DHX9, SERPINH1, ATIC, PIK3R2, PIK3R1, PIK3CD, PIK3CB, PIK3CA, PIK3C2B, SERPINB6, LYZ, KRT19, KRT17, KRT16, KR
Protein Size: 304

Molecular Weight: 34 kDa

Gene ID: 1398

NCBI Accession: NM_016823, NP_058431

UniProt: P46108

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor