beta Arrestin 1 antibody (Middle Region)

Catalog No. ABIN2779340

This Rabbit Polyclonal antibody specifically detects beta Arrestin 1 in WB. It exhibits reactivity toward Human, Cow, Horse and Dog.

Quick Overview for beta Arrestin 1 antibody (Middle Region) (ABIN2779340)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reactivity: Human, Cow, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Arrestin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-beta Arrestin 1 Antibody

Binding Specificity: Middle Region

Purpose: ARRB1 Antibody - middle region

Sequence: NETPVDTNLI ELDTNDDDIV FEDFARQRLK GMKDDKEEEE DGTGSPQLNN

Predicted Reactivity: Cow: 90%, Dog: 100%, Horse: 100%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ARRB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ARRB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30523-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Alternative Name: ARRB1

Background:

Background Information: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.

Gene Name: Arrestin, beta 1

Alternative Symbols: ARB1, ARR1

Protein Name: Beta-arrestin-1

Molecular Weight: 47kDa

Gene ID: 408

NCBI Accession: NP_004032

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction