TNFRSF10A antibody (C-Term)

Catalog No. ABIN2779352

The Rabbit Polyclonal anti-TNFRSF10A antibody is suitable to detect TNFRSF10A in samples from Human and Mouse. It has been validated for WB.

Quick Overview for TNFRSF10A antibody (C-Term) (ABIN2779352)

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF10A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNFRSF10A Antibody

Binding Specificity: C-Term

Sequence: RAGTAGPGDA LYAMLMKWVN KTGRNASIHT LLDALERMEE RHAKEKIQDL

Predicted Reactivity: Human: 100%, Mouse: 80%

Characteristics: This is a rabbit polyclonal antibody against TNFRSF10A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 468 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Alternative Name: TNFRSF10A

Background: This is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
Alias Symbols: APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Protein Interaction Partner: UBC, MARCH8, MARCH1, CFLAR, FADD, CUL3, TRAF2, CASP8, SQSTM1, TNFRSF10B, CBL, MOAP1, RASSF1, TNFRSF10D, TNFRSF10A, TNFSF10, MADD, BCL10, TRADD, RIPK1, DAP3, BTK, CD4, COL2A1, CASP10,
Protein Size: 468

Molecular Weight: 50 kDa

Gene ID: 8797

NCBI Accession: NM_003844, NP_003835

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity