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LMX1A antibody (Middle Region)

LMX1A Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2779408
  • Target See all LMX1A Antibodies
    LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))
    Binding Specificity
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 24
    • 18
    • 9
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit
    Host
    • 27
    Rabbit
    Clonality
    • 27
    Polyclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 1
    • 1
    This LMX1A antibody is un-conjugated
    Application
    • 22
    • 15
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    QNQRAKMKKL ARRQQQQQQD QQNTQRLSSA QTNGGGSAGM EGIMNPYTAL
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against LMX1A. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human LMX1A
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 382 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))
    Alternative Name
    LMX1A (LMX1A Products)
    Synonyms
    Lmx1.1 antibody, dr antibody, dreher antibody, sst antibody, LMX1 antibody, LMX1.1 antibody, si:ch211-260g14.3 antibody, LIM homeobox transcription factor 1 alpha antibody, LIM homeobox transcription factor 1, alpha antibody, Lmx1a antibody, LMX1A antibody, lmx1a antibody
    Background
    Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 AL160058.8 14249-14447 c 200-2447 AK127724.1 362-2609 2448-3382 AL390730.12 9415-10349 c
    Alias Symbols: LMX-1, LMX1, LMX1.1, MGC87616
    Protein Interaction Partner: LDB1, BMPR2, ISL1, LHX3, LMX1A, TCF3,
    Protein Size: 382
    Molecular Weight
    43 kDa
    Gene ID
    4009
    NCBI Accession
    NM_177398, NP_796372
    UniProt
    Q8TE12
    Pathways
    Dopaminergic Neurogenesis
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