PAWR antibody (Middle Region)

Catalog No. ABIN2779443

This Rabbit Polyclonal antibody specifically detects PAWR in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Horse, Rabbit and Guinea Pig.

Quick Overview for PAWR antibody (Middle Region) (ABIN2779443)

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAWR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PAWR Antibody

Binding Specificity: Middle Region

Purpose: PAWR Antibody - middle region

Sequence: VNIPAAECLD EYEDDEAGQK ERKREDAITQ QNTIQNEAVN LLDPGSSYLL

Predicted Reactivity: Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PAWR. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PAWR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8108907

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Alternative Name: PAWR

Background:

Background Information: The tumor suppressor WT1 represses and activates transcription. Anti-Prostate Apoptosis Response Protein Par-4 (PAWR) is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.

Gene Name: PRKC, apoptosis, WT1, regulator

Alternative Symbols: PAR4, Par-4

Protein Name: PRKC apoptosis WT1 regulator protein

Molecular Weight: 37kDa

Gene ID: 5074

NCBI Accession: NP_002574

UniProt: O75796