ESRRA antibody (C-Term)

Catalog No. ABIN2779529

Product Details anti-ESRRA Antibody

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRRA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AGRAGPGGGA ERRRAGRLLL TLPLLRQTAG KVLAHFYGVK LEGKVPMHKL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Esrra. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 422 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ESRRA

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Alternative Name: Esrra (ESRRA Products)

Synonyms: err1 antibody, erra antibody, esrral antibody, erralpha antibody, nr3b1 antibody, MGC80854 antibody, ESRRA antibody, esrl1 antibody, LOC100125507 antibody, ERRalpha antibody, Err1 antibody, Estrra antibody, Nr3b1 antibody, Errra antibody, ERR1 antibody, ERRa antibody, ESRL1 antibody, NR3B1 antibody, ESTRRA antibody, estrogen-related receptor alpha antibody, estrogen related receptor alpha L homeolog antibody, estrogen related receptor alpha antibody, catsper channel auxiliary subunit zeta antibody, estrogen related receptor, alpha antibody, esrra antibody, esrra.L antibody, ESRRA antibody, LOC100125507 antibody, CATSPERZ antibody, Esrra antibody

Background: Esrra binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. It can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. It binds to the C1 region of the lactoferrin gene promoter. It requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
Alias Symbols: ERRalpha, Err1, Estrra, Nr3b1
Protein Interaction Partner: Ubc, Sirt1, Hdac8, Kat2b, Crebzf, Esrrb, Ppargc1a,
Protein Size: 422

Molecular Weight: 45 kDa

Gene ID: 26379

NCBI Accession: NM_007953, NP_031979

UniProt: O08580

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha