ZUFSP antibody (Middle Region)

Catalog No. ABIN2779538

This Rabbit Polyclonal antibody specifically detects ZUFSP in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Rabbit, Horse and Pig.

Quick Overview for ZUFSP antibody (Middle Region) (ABIN2779538)

Target: ZUFSP (Zinc Finger with UFM1-Specific Peptidase Domain (ZUFSP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZUFSP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZUFSP Antibody

Binding Specificity: Middle Region

Purpose: ZUP1 Antibody - middle region

Sequence: RQEIEEFQKL QRQYGLDNSG GYKQQQLRNM EIEVNRGRMP PSEFHRRKAD

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against C6orf113. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human C6orf113

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32274-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZUFSP

Target: ZUFSP (Zinc Finger with UFM1-Specific Peptidase Domain (ZUFSP))

Alternative Name: ZUP1

Background:

Background Information: This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers.

Gene Name: zinc finger containing ubiquitin peptidase 1

Alternative Symbols: DUB, ZUFSP, C6orf113

Protein Name: zinc finger-containing ubiquitin peptidase 1

Molecular Weight: 66kDa

Gene ID: 221302

NCBI Accession: NP_659499

UniProt: Q96AP4