EYA3 antibody (N-Term)

Catalog No. ABIN2779570

This Rabbit Polyclonal antibody specifically detects EYA3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Horse, Sheep and Dog.

Quick Overview for EYA3 antibody (N-Term) (ABIN2779570)

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Horse, Sheep, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EYA3 Antibody

Binding Specificity: N-Term

Purpose: EYA3 Antibody - N-terminal region

Sequence: KMQESGEQTI SQVSNPDVSD QKPETSSLAS NLPMSEEIMT CTDYIPRSSN

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against EYA3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human EYA3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32330-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for EYA3

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Alternative Name: EYA3

Background:

Background Information: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: EYA transcriptional coactivator and phosphatase 3

Protein Name: eyes absent homolog 3

Molecular Weight: 39kDa

Gene ID: 2140

NCBI Accession: NP_001269489

UniProt: Q99504

Pathways: Positive Regulation of Response to DNA Damage Stimulus