ACD antibody (C-Term)

Catalog No. ABIN2779815

This Rabbit Polyclonal antibody specifically detects ACD in WB. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Guinea Pig and Horse.

Quick Overview for ACD antibody (C-Term) (ABIN2779815)

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACD Antibody

Binding Specificity: C-Term

Purpose: Acd Antibody - C-terminal region

Sequence: PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA

Predicted Reactivity: Cow: 83%, Dog: 85%, Guinea Pig: 85%, Horse: 85%, Human: 85%, Mouse: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Acd. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the c terminal region of mouse Acd

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36813-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ACD

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Alternative Name: Acd

Background:

Background Information: Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.

Gene Name: Adrenocortical dysplasia

Alternative Symbols: -

Protein Name: Adrenocortical dysplasia protein

Molecular Weight: 45

Gene ID: 497652

NCBI Accession: NP_001012656

UniProt: Q5EE38

Pathways: Telomere Maintenance