Arx antibody (Middle Region)

Catalog No. ABIN2779819

Cited in 2+ publications. The Rabbit Polyclonal anti-Arx antibody (ABIN2779819) specifically detects Arx in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Rabbit, Guinea Pig and Horse samples.

Quick Overview for Arx antibody (Middle Region) (ABIN2779819)

Target: Arx (ARX) (Aristaless Related Homeobox (ARX))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Arx antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Arx Antibody

Binding Specificity: Middle Region

Purpose: ARX Antibody - middle region

Sequence: TGAEDDEEEL LEDEEDEEEE EELLEDDDEE LLEDDARALL KEPRRCSVAT

Predicted Reactivity: Dog: 93%, Guinea Pig: 93%, Horse: 79%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ARX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse ARX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8094954

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Arx antibody (ABIN2779819)

Price, Yoo, Burgess, Deng, Hrachovy, Frost, Noebels et al.: "A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral ..." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 27, pp. 8752-63, (2009) (PubMed).

Condomines, Hose, Rème, Requirand, Hundemer, Schoenhals, Goldschmidt, Klein: "Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 832-40, (2009) (PubMed).

Target Details for Arx

Target: Arx (ARX) (Aristaless Related Homeobox (ARX))

Alternative Name: ARX

Background:

Background Information: ARX (Aristaless-related genes), a subset of the Paired-related homeobox genes, is a group of regulators of essential events during vertebrate embryogenesis. Arx was highly conserved between mouse and zebrafish. Studies have disclosed its neuromeric expression in the forebrain and longitudinal expression in the floor plate in mouse and zebrafish. It is also expressed in the dorsal telencephalon (presumptive cerebral cortex) of mouse embryos.

Gene Name: Aristaless related homeobox

Alternative Symbols: Ar, Arx1

Protein Name: Homeobox protein ARX

Molecular Weight: 58kDa

Gene ID: 11878

NCBI Accession: NP_031518

UniProt: O35085