Menin antibody (Middle Region)

Catalog No. ABIN2779869

This Rabbit Polyclonal antibody specifically detects Menin in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Horse and Pig.

Quick Overview for Menin antibody (Middle Region) (ABIN2779869)

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Menin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Menin Antibody

Binding Specificity: Middle Region

Sequence: YNYCREDEEI YKEFFEVAND VIPNLLKEAA SLLETGEERT GEQAQGTQGQ

Predicted Reactivity: Cow: 85%, Guinea Pig: 85%, Horse: 85%, Human: 85%, Mouse: 100%, Pig: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against Men1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 611 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: Men1

Background: Men1 may be involved in DNA repair. Men1 is a component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.
Alias Symbols: AW045611
Protein Interaction Partner: Eed, Nanog, Jund, Smad5, Runx2, Kmt2d, Nfe2, Pparg, Rhox5,
Protein Size: 611

Molecular Weight: 67 kDa

Gene ID: 17283

NCBI Accession: NM_008583, NP_032609

UniProt: O88559

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity