TFAM antibody (Middle Region)

Catalog No. ABIN2779902

This Rabbit Polyclonal antibody specifically detects TFAM in WB. It exhibits reactivity toward Mouse, Rat and Rabbit.

Quick Overview for TFAM antibody (Middle Region) (ABIN2779902)

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivity: Mouse, Rat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TFAM Antibody

Binding Specificity: Middle Region

Sequence: SESFQEAKDD SAQGKLKLVN EAWKNLSPEE KQAYIQLAKD DRIRYDNEMK

Predicted Reactivity: Mouse: 100%, Rabbit: 77%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against TFAM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse TFAM

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 243 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Alternative Name: TFAM

Background: TFAM a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this protein is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns Sayre syndrome was produced when expression of the gene was eliminated by targeted disruption in heart and muscle cells.
Alias Symbols: Hmgts, mtTFA, tsHMG, AI661103
Protein Interaction Partner: C1QBP, SNCA,
Protein Size: 243

Molecular Weight: 27 kDa

Gene ID: 21780

NCBI Accession: NM_009360, NP_033386

UniProt: P40630

Pathways: Chromatin Binding