SREBF1 antibody (N-Term)

Catalog No. ABIN2779970

This Rabbit Polyclonal antibody specifically detects SREBF1 in WB. It exhibits reactivity toward Rat and Mouse.

Quick Overview for SREBF1 antibody (N-Term) (ABIN2779970)

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SREBF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SREBF1 Antibody

Binding Specificity: N-Term

Sequence: DIEDMLQLIN NQDSDFPGLF DAPYAGGETG DTGPSSPGAN SPESFSSASL

Predicted Reactivity: Mouse: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SREBF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse SREBF1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1134 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SREBF1

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Alternative Name: SREBF1

Background: Srebf1 is transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Srebf1 also binds to an E-box motif (5'-ATCACGTGA-3'). Srebf1 regulates the transcription of genes for sterol biosynthesis and the LDL receptor gene.
Alias Symbols: ADD1, ADD-1, SREBP1, bHLHd1, SREBP-1, SREBP1c, SREBP-1a, SREBP-1c, D630008H06
Protein Interaction Partner: Rnf20, Zbtb7c, Ppargc1b, Rela, Ewsr1, Pcbd1,
Protein Size: 1134

Molecular Weight: 125 kDa

Gene ID: 20787

NCBI Accession: NM_011480, NP_035610

UniProt: Q9WTN3

Pathways: AMPK Signaling, Caspase Cascade in Apoptosis, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha