FIGLA antibody (C-Term)

Catalog No. ABIN2779982

Product Details anti-FIGLA Antibody

Target: FIGLA (Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA))

Binding Specificity: C-Term

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIGLA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSTRELLGNA TQPTSCASGL KKEEEGPWAY AGHSEPLYSY HQSTVPETRS

Predicted Reactivity: Mouse: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against Figla. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Figla

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FIGLA

Target: FIGLA (Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA))

Alternative Name: Figla (FIGLA Products)

Synonyms: bHLHc8 antibody, BHLHC8 antibody, FIGALPHA antibody, POF6 antibody, RGD1564754 antibody, bhlhc8 antibody, figalpha antibody, figla antibody, pof6 antibody, FIGalpha antibody, fig1a antibody, zgc:109752 antibody, folliculogenesis specific basic helix-loop-helix antibody, folliculogenesis specific bHLH transcription factor antibody, folliculogenesis specific bHLH transcription factor L homeolog antibody, Figla antibody, FIGLA antibody, figla.L antibody, figla antibody

Background: Figla is a germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. It plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. It is essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Figla binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
Alias Symbols: bHLHc8
Protein Size: 194

Molecular Weight: 21 kDa

Gene ID: 26910

NCBI Accession: NM_012013, NP_036143

UniProt: O55208