RYBP antibody (N-Term)

Catalog No. ABIN2780023

The Rabbit Polyclonal anti-RYBP antibody is suitable to detect RYBP in samples from Human, Mouse, Rat, Cow, Dog, Saccharomyces cerevisiae, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for RYBP antibody (N-Term) (ABIN2780023)

Target: RYBP (RING1 and YY1 Binding Protein (RYBP))

Reactivity: Human, Mouse, Rat, Cow, Dog, Saccharomyces cerevisiae, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYBP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RYBP Antibody

Binding Specificity: N-Term

Purpose: Rybp Antibody - N-terminal region

Sequence: RINSQLVAQQ VAQQYATPPP PKKEKKEKVE KPDKEKPEKD KDISPSVTKK

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 92%, Human: 92%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 75%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against Rybp. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Rybp

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37264-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for RYBP

Target: RYBP (RING1 and YY1 Binding Protein (RYBP))

Alternative Name: Rybp

Background:

Background Information: Rybp inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. It may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 and may bind to DNA. It promotes apoptosis.

Gene Name: RING1 and YY1 binding protein

Alternative Symbols: DEDA, DEDAF, YEAF1, 2410018J24Rik

Protein Name: RING1 and YY1-binding protein

Molecular Weight: 25kDa

Gene ID: 56353

NCBI Accession: NP_062717

UniProt: Q8CCI5