TAF1A antibody (N-Term)

Catalog No. ABIN2780033

Product Details anti-TAF1A Antibody

Target: TAF1A (TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa (TAF1A))

Binding Specificity: N-Term

Reactivity: Rat, Mouse, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAF1A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FAQTTSACLS FLQEALLKHQ WCRAAEYMHS YLQTLEDSDT YRKQAAPEII

Predicted Reactivity: Guinea Pig: 86%, Horse: 91%, Mouse: 100%, Rabbit: 92%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Taf1a. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Taf1a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TAF1A antibody (ABIN2780033)

Machida, Takeda, Yokono, Ikemune, Taniguchi, Kiyosawa, Takemasa: "Reduction of ribosome biogenesis with activation of the mTOR pathway in denervated atrophic muscle." in: Journal of cellular physiology, Vol. 227, Issue 4, pp. 1569-76, (2012) (PubMed).

Target Details for TAF1A

Target: TAF1A (TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa (TAF1A))

Alternative Name: Taf1a (TAF1A Products)

Synonyms: TAFI48 antibody, mTAFI48 antibody, MGC:17061 antibody, RAFI48 antibody, SL1 antibody, TATA-box binding protein associated factor, RNA polymerase I, A antibody, TATA-box binding protein associated factor, RNA polymerase I subunit A antibody, Taf1a antibody, TAF1A antibody

Background: Taf1a is a component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Alias Symbols: -
Protein Size: 453

Molecular Weight: 49 kDa

Gene ID: 360893

NCBI Accession: NM_001037204, NP_001032281

UniProt: Q3B7U2