ONECUT2 antibody (N-Term)

Catalog No. ABIN2780236

This Rabbit Polyclonal antibody specifically detects ONECUT2 in WB. It exhibits reactivity toward Human, Mouse, Guinea Pig and Rat.

Quick Overview for ONECUT2 antibody (N-Term) (ABIN2780236)

Target: ONECUT2 (One Cut Homeobox 2 (ONECUT2))

Reactivity: Human, Mouse, Guinea Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ONECUT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ONECUT2 Antibody

Binding Specificity: N-Term

Purpose: ONECUT2 Antibody - N-terminal region

Sequence: TSMASILDGG DYRPELSIPL HHAMSMSCDS SPPGMGMSNT YTTLTPLQPL

Predicted Reactivity: Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ONECUT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ONECUT2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37740-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ONECUT2

Target: ONECUT2 (One Cut Homeobox 2 (ONECUT2))

Alternative Name: ONECUT2

Background:

Background Information: ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism. This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.

Gene Name: One cut homeobox 2

Alternative Symbols: OC2, OC-2

Protein Name: One cut domain family member 2

Molecular Weight: 54kDa

Gene ID: 9480

NCBI Accession: NP_004843

UniProt: O95948