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RFX5 antibody (C-Term)

RFX5 Reactivity: Human, Mouse, Rat, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2780343
  • Target See all RFX5 Antibodies
    RFX5 (Regulatory Factor X 5 (RFX5))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 34
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat, Guinea Pig, Horse
    Host
    • 31
    • 3
    • 1
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 26
    • 2
    • 2
    • 2
    • 2
    • 2
    This RFX5 antibody is un-conjugated
    Application
    • 33
    • 20
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    VIKGSRSQKE AFPLAKGEVD TAPQGNKDLK EHVLQSSLSQ EHKDPKATPP
    Predicted Reactivity
    Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rat: 86%
    Characteristics
    This is a rabbit polyclonal antibody against RFX5. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human RFX5
    Top Product
    Discover our top product RFX5 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 616 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    RFX5 (Regulatory Factor X 5 (RFX5))
    Alternative Name
    RFX5 (RFX5 Products)
    Synonyms
    regulatory factor X5 antibody, regulatory factor X, 5 (influences HLA class II expression) antibody, RFX5 antibody, Rfx5 antibody
    Background
    RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. RFX is a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS, MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS, MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS, MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
    Alias Symbols: -
    Protein Interaction Partner: UBC, MRPL53, SLIRP, SRPRB, CDV3, LSM7, RPS19, RBMS1, NDUFA7, NDUFA2, ANKRA2, RFXANK, MLLT1, HDAC4, CIITA, HDAC2, RFXAP,
    Protein Size: 616
    Molecular Weight
    65 kDa
    Gene ID
    5993
    NCBI Accession
    NM_000449, NP_000440
    UniProt
    P48382
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