IRF1 antibody (C-Term)

Catalog No. ABIN2780409

This Rabbit Polyclonal antibody specifically detects IRF1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Sheep and Horse.

Quick Overview for IRF1 antibody (C-Term) (ABIN2780409)

Target: IRF1 (Interferon Regulatory Factor 1 (IRF1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Sheep, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-IRF1 Antibody

Binding Specificity: C-Term

Sequence: YLLNEPGVQP TSVYGDFSCK EEPEIDSPGG DIGLSLQRVF TDLKNMDATW

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against IRF1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of IRF1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 325 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IRF1

Target: IRF1 (Interferon Regulatory Factor 1 (IRF1))

Alternative Name: IRF1

Background: IRF1 is interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
Alias Symbols: IRF-1, MAR
Protein Interaction Partner: SUMO2, SUMO3, IRF2, KAT2B, EP300, PRDM1, UBC, BIRC3, MDM2, HIST1H3A, CBL, HSP90AA1, HSPA1A, Tbk1, STUB1, SPI1, QARS, IRF8, CDKN1B, TRIM28, SET, SP2, IRF9, YBX1, NPM1, TRMT2A, HCFC1, SEC63, KEAP1, TRAF3, CREBBP, tat, SMARCA4, STAT1, HMGA1, RELA, NFKB1, KAT
Protein Size: 325

Molecular Weight: 36 kDa

Gene ID: 3659

NCBI Accession: NM_002198, NP_002189

UniProt: P10914

Pathways: Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagy