PURA antibody (N-Term)

Catalog No. ABIN2780716

The Rabbit Polyclonal anti-PURA antibody is suitable to detect PURA in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Sheep, Guinea Pig and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for PURA antibody (N-Term) (ABIN2780716)

Target: PURA (Purine-Rich Element Binding Protein A (PURA))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Sheep, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PURA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PURA Antibody

Binding Specificity: N-Term

Purpose: PURA Antibody - N-terminal region

Sequence: GGGGGGGGSG GGGGGAPGGL QHETQELASK RVDIQNKRFY LDVKQNAKGR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PURA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PURA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38688-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PURA

Target: PURA (Purine-Rich Element Binding Protein A (PURA))

Alternative Name: PURA

Background:

Background Information: PURA is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Purine-rich element binding protein A

Alternative Symbols: PUR1, MRD31, PURALPHA, PUR-ALPHA

Protein Name: Transcriptional activator protein Pur-alpha

Molecular Weight: 35kDa

Gene ID: 5813

NCBI Accession: NP_005850

UniProt: Q00577