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RELB antibody (Middle Region)

This Rabbit Polyclonal antibody specifically detects RELB in WB. It exhibits reactivity toward Human, Dog, Cow, Horse and Pig.
Catalog No. ABIN2780785

Quick Overview for RELB antibody (Middle Region) (ABIN2780785)

Target

See all RELB Antibodies
RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

Reactivity

  • 108
  • 75
  • 36
  • 11
  • 11
  • 7
  • 6
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
Human, Dog, Cow, Horse, Pig

Host

  • 107
  • 7
Rabbit

Clonality

  • 97
  • 17
Polyclonal

Conjugate

  • 67
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This RELB antibody is un-conjugated

Application

  • 91
  • 29
  • 27
  • 27
  • 22
  • 19
  • 16
  • 12
  • 11
  • 11
  • 7
  • 2
  • 2
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 16
    • 15
    • 11
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequence

    DLLPPAPPHA SAVVCSGGAG AVVGETPGPE PLTLDSYQAP GPGDGGTASL

    Predicted Reactivity

    Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Pig: 86%

    Characteristics

    This is a rabbit polyclonal antibody against RELB. It was validated on Western Blot using a cell lysate as a positive control.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human RELB
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 579 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

    Alternative Name

    RELB

    Background

    NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
    Alias Symbols: I-REL, IREL, REL-B
    Protein Interaction Partner: NFKB2, NFKB1, BCL3, NEK6, DNMT1, DAXX, MT1M, GSK3B, CTSL, CDK1, BUD31, UQCRFS1, MTAP, COMMD9, COMMD5, MALT1, COMMD1, COMMD8, COMMD4, COMMD10, COMMD2, UBC, RAC1, SUZ12, RELA, EZH2, DPF2, YY1, CBX3, EHMT2, NFKBIA, KPNA6, SMARCA4, SMARCE1, SMARCC2, SMARCC1,
    Protein Size: 579

    Molecular Weight

    62 kDa

    Gene ID

    5971

    NCBI Accession

    NM_006509, NP_006500

    UniProt

    Q01201

    Pathways

    NF-kappaB Signaling, RTK Signaling
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