Coronin 1a antibody (N-Term)

Catalog No. ABIN2780826

This Rabbit Polyclonal antibody specifically detects Coronin 1a in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for Coronin 1a antibody (N-Term) (ABIN2780826)

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coronin 1a antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Coronin 1a Antibody

Binding Specificity: N-Term

Sequence: MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against CORO1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CORO1A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 461 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Coronin 1a

Target: Coronin 1a (CORO1A) (Coronin, Actin Binding Protein, 1A (CORO1A))

Alternative Name: CORO1A

Background: CORO1A is a novel actin-binding protein with a WD repeat and a leucine zipper motif. CORO1A forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell. The leukocyte plasma membrane associates with the actin cytoskeleton through CORO1A.Downregulation of CORO1A gene transcription restricts entry/survival of mycobacteria within macrophages
Alias Symbols: p57, TACO, CLABP, HCORO1, CLIPINA
Protein Interaction Partner: FSD2, GOLGA2, UBC, YTHDC1, SPATA20, POT1, TAB1, GIT2, POLR1C, STAT3, SMARCD1, MAGOH, SMAD3, LMO2, FHL3, FMNL1, NCF4, THBS1, ACTB, DKK1, UBE2G2,
Protein Size: 461

Molecular Weight: 51 kDa

Gene ID: 11151

NCBI Accession: NM_007074, NP_009005

UniProt: Q2YD73

Pathways: Regulation of Actin Filament Polymerization