CoREST antibody (N-Term)

Catalog No. ABIN2780965

This Rabbit Polyclonal antibody specifically detects CoREST in WB and IHC. It exhibits reactivity toward Human, Mouse and Zebrafish (Danio rerio)and has been mentioned in 1 publication.

Quick Overview for CoREST antibody (N-Term) (ABIN2780965)

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Reactivity: Human, Mouse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CoREST antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CoREST Antibody

Binding Specificity: N-Term

Sequence: MVEKGPEVSG KRRGRNNAAA SASAAAASAA ASAACASPAA TAASGAAASS

Predicted Reactivity: Human: 100%, Mouse: 100%, Zebrafish: 90%

Characteristics: This is a rabbit polyclonal antibody against RCOR1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RCOR1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 482 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CoREST antibody (ABIN2780965)

Packer, Xing, Harper, Jones, Davidson: "The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 53, pp. 14341-6, (2009) (PubMed).

Target Details for CoREST

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Alternative Name: RCOR1

Background: RCOR1 is a functional corepressor required for regulation of neural-specific gene expression.The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.[supplied by OMIM].
Alias Symbols: COREST, KIAA0071, RCOR
Protein Interaction Partner: HDAC1, UBC, KDM1A, HDAC2, HDAC3, NPM1, MTA3, TP53BP1, NR2C1, TCF3, HMG20B, RCOR1, SNAI1, SUMO2, Dynll1, HIST3H3, TAL1, GFI1, GFI1B, MED28, OBFC1, SUB1, MED12, TRIP4, BCL3, ESCO2, SERPINH1, ZNF217, EMD, CTBP1, RL2, NR2E1, REST, HIST1H3A, SMARCE1, SMARCC2,
Protein Size: 482

Molecular Weight: 53 kDa

Gene ID: 23186

NCBI Accession: NM_015156, NP_055971

UniProt: Q9UKL0

Pathways: Regulation of Hormone Metabolic Process, Chromatin Binding