CoREST antibody (AA 394-482)

Catalog No. ABIN7167721

Product Details anti-CoREST Antibody

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Binding Specificity: AA 394-482

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CoREST antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human REST corepressor 1 protein (394-482AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CoREST

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Alternative Name: RCOR1 (RCOR1 Products)

Synonyms: COREST antibody, RCOR antibody, 5730409O11 antibody, 6720480E22Rik antibody, AU042633 antibody, D12Wsu95e antibody, mKIAA0071 antibody, rcor1 antibody, xcoREST antibody, RCOR1 antibody, im:6904264 antibody, si:dkey-46n18.7 antibody, zgc:158607 antibody, RGD1305743 antibody, REST corepressor 1 antibody, REST corepressor 1 L homeolog antibody, RCOR1 antibody, Rcor1 antibody, rcor1.L antibody, rcor1 antibody

Background:

Background: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Aliases: COREST antibody, KIAA0071 antibody, Nr2b2 antibody, Nuclear receptor coregulator 1 antibody, Nuclear receptor subfamily 2 group B member 2 antibody, Protein CoREST antibody, RCOR antibody, Rcor1 antibody, RCOR1_HUMAN antibody, REST corepressor 1 antibody, Retinoic acid receptor RXR-beta antibody, Retinoid X receptor beta antibody, Rxrb antibody

UniProt: Q9UKL0

Pathways: Regulation of Hormone Metabolic Process, Chromatin Binding