SUZ12 antibody (C-Term)

Catalog No. ABIN2780973

There is 1 publication for this product available. The Rabbit Polyclonal anti-SUZ12 antibody is suitable to detect SUZ12 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Guinea Pig. It has been validated for WB.

Quick Overview for SUZ12 antibody (C-Term) (ABIN2780973)

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUZ12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SUZ12 Antibody

Binding Specificity: C-Term

Purpose: SUZ12 Antibody - C-terminal region

Sequence: ESASPANEEI TEEQNGTANG FSEINSKEKA LETDSVSGVS KQSKKQKL

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SUZ12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SUZ12

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8113156

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-SUZ12 antibody (ABIN2780973)

De Cegli, Iacobacci, Flore, Gambardella, Mao, Cutillo, Lauria, Klose, Illingworth, Banfi, di Bernardo: "Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation." in: Nucleic acids research, Vol. 41, Issue 2, pp. 711-26, (2013) (PubMed).

Target Details for SUZ12

Target: SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))

Alternative Name: SUZ12

Background:

Background Information: A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7,17)(p15,q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Suppressor of zeste 12 homolog (Drosophila)

Alternative Symbols: CHET9, IMMAS, JJAZ1

Protein Name: Polycomb protein SUZ12

Molecular Weight: 83kDa

Gene ID: 23512

NCBI Accession: NP_056170

UniProt: Q15022