PRRX2 antibody (N-Term)

Catalog No. ABIN2781006

This Rabbit Polyclonal antibody specifically detects PRRX2 in WB. It exhibits reactivity toward Mouse, Human, Rat, Cow, Dog, Horse, Pig, Guinea Pig, Rabbit and Zebrafish (Danio rerio).It has been mentioned in 1 publication

Quick Overview for PRRX2 antibody (N-Term) (ABIN2781006)

Target: PRRX2 (Paired Related Homeobox 2 (PRRX2))

Reactivity: Mouse, Human, Rat, Cow, Dog, Horse, Pig, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRRX2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRRX2 Antibody

Binding Specificity: N-Term

Purpose: PRRX2 Antibody - N-terminal region

Sequence: RKNFSVSHLL DLEEVAAAGR LAARPGARAE AREGAAREPS GGSSGSEAAP

Predicted Reactivity: Cow: 79%, Dog: 79%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 79%, Rat: 79%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PRRX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRRX2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39248-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PRRX2 antibody (ABIN2781006)

Tokutomi, Araki, Kataoka, Yamamoto, Kim-Mitsuyama: "Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis." in: Biochemical and biophysical research communications, Vol. 364, Issue 4, pp. 822-30, (2007) (PubMed).

Target Details for PRRX2

Target: PRRX2 (Paired Related Homeobox 2 (PRRX2))

Alternative Name: PRRX2

Background:

Background Information: PRRX2 is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.

Gene Name: Paired related homeobox 2

Alternative Symbols: PMX2, PRX2

Protein Name: Paired mesoderm homeobox protein 2

Molecular Weight: 27kDa

Gene ID: 51450

NCBI Accession: NP_057391

UniProt: Q99811