CBX4 antibody (Middle Region)

Catalog No. ABIN2781104

This anti-CBX4 antibody is a Rabbit Polyclonal antibody detecting CBX4 in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio) and Horse.

Quick Overview for CBX4 antibody (Middle Region) (ABIN2781104)

Target: CBX4 (Chromobox Homolog 4 (CBX4))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CBX4 Antibody

Binding Specificity: Middle Region

Sequence: KWRGWSPKYN TWEPEENILD PRLLIAFQNR ERQEQLMGYR KRGPKPKPLV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CBX4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human CBX4

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CBX4

Target: CBX4 (Chromobox Homolog 4 (CBX4))

Alternative Name: CBX4

Background: CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. It monosumoylates ZNF131.
Protein Interaction Partner: Rnf111, SUMO1, NEDD8, CBS, BMI1, EED, RNF2, HECW2, SOX2, YWHAE, YWHAB, CCDC158, DIS3L2, HIST4H4, CBX2, PARP12, RNF213, ZKSCAN7, DCAF6, KDM3A, MYCBP2, ANKRD26, PSME3, TRANK1, CBX4, HIST1H2AB, YWHAZ, SKIL, NPM1, HIST1H2BB, GTF2I, PHC2, CSNK2B, CSNK2A2, CSNK
Protein Size: 290

Molecular Weight: 31 kDa

Gene ID: 8535