GATAD2B antibody (N-Term)

Catalog No. ABIN2781110

The Rabbit Polyclonal anti-GATAD2B antibody (ABIN2781110) specifically detects GATAD2B in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Guinea Pig, Rabbit, Dog, Horse and Zebrafish (Danio rerio) samples.

Quick Overview for GATAD2B antibody (N-Term) (ABIN2781110)

Target: GATAD2B (GATA Zinc Finger Domain Containing 2B (GATAD2B))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Rabbit, Dog, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GATAD2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GATAD2B Antibody

Binding Specificity: N-Term

Purpose: GATAD2B Antibody - N-terminal region

Sequence: MDRMTEDALR LNLLKRSLDP ADERDDVLAK RLKMEGHEAM ERLKMLALLK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against GATAD2B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GATAD2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101381

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GATAD2B

Target: GATAD2B (GATA Zinc Finger Domain Containing 2B (GATAD2B))

Alternative Name: GATAD2B

Background:

Background Information: Hp66beta (GATAD2B), previously identified as a component of the human MeCP1 complex, is a second member of a p66 gene family (hp66alpha and hp66beta). Both proteins interact with MBD2 and MBD3 functionally and biochemically. Both factors function in synergy, since knocking-down p66alpha affects the repressive function of p66beta and vice versa. Furthermore, confocal microscopy shows a nuclear colocalization of hp66alpha with hp66beta and MBD2 in a speckled pattern. These two highly related mammalian p66 proteins display overlapping functions and are involved in methylation dependent transcriptional repression.

Gene Name: GATA zinc finger domain containing 2B

Alternative Symbols: p68, GANDS, MRD18, P66beta

Protein Name: Transcriptional repressor p66-beta

Molecular Weight: 65kDa

Gene ID: 57459

NCBI Accession: NP_065750

UniProt: Q8WXI9