AHRR antibody (Middle Region)

Catalog No. ABIN2781113

This Rabbit Polyclonal antibody specifically detects AHRR in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Cow and Guinea Pig.

Quick Overview for AHRR antibody (Middle Region) (ABIN2781113)

Target: AHRR (Aryl-Hydrocarbon Receptor Repressor (AHRR))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AHRR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AHRR Antibody

Binding Specificity: Middle Region

Purpose: AHRR Antibody - middle region

Sequence: LPQSEPPHQL CARGRGEQSC TCRAAEAAPV VKREPLDSPQ WATHSQGMVP

Predicted Reactivity: Cow: 82%, Dog: 85%, Guinea Pig: 91%, Horse: 79%, Human: 100%, Mouse: 91%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against AHRR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AHRR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39438-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for AHRR

Target: AHRR (Aryl-Hydrocarbon Receptor Repressor (AHRR))

Alternative Name: AHRR

Background:

Background Information: Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor's binding partner, arylhydrocarbon receptor nuclear translocator. AHRR represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, AHRR can bind to nuclear factor kappa-B.Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor's binding partner, arylhydrocarbon receptor nuclear translocator. The protein encoded by this gene represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Aryl-hydrocarbon receptor repressor

Alternative Symbols: AHH, AHHR, bHLHe77

Protein Name: Aryl hydrocarbon receptor repressor

Molecular Weight: 78kDa

Gene ID: 57491

NCBI Accession: NP_065782

UniProt: A9YTQ3

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha