TRIM11 antibody (C-Term)
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- Target See all TRIM11 Antibodies
- TRIM11 (Tripartite Motif Containing 11 (TRIM11))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRIM11 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GSFYNSNEPA FSPLRDPPKR VGIFLDYEAG HLSFYSATDG SLLFIFPETL
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against Trim11. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Top Product
- Discover our top product TRIM11 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 467 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TRIM11 (Tripartite Motif Containing 11 (TRIM11))
- Alternative Name
- Trim11 (TRIM11 Products)
- Synonyms
- BIA1 antibody, RNF92 antibody, TRIM11 antibody, tripartite motif containing 11 antibody, tripartite motif-containing 11 antibody, TRIM11 antibody, Trim11 antibody
- Background
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Trim11 is an E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. It may also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. It may contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. It mediates MED15 ubiquitination leading to proteasomal degradation. Trim11 may contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. Trim11 may regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Alias Symbols: -
Protein Interaction Partner: TBK1, Pax6, Phox2b,
Protein Size: 467 - Molecular Weight
- 52 kDa
- Gene ID
- 94091
- NCBI Accession
- NM_053168, NP_444398
- UniProt
- Q99PQ2
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