STEAP3 antibody (N-Term)

Catalog No. ABIN2781309

This Rabbit Polyclonal antibody specifically detects STEAP3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit and Pig.

Quick Overview for STEAP3 antibody (N-Term) (ABIN2781309)

Target: STEAP3 (STEAP Family Member 3, Metalloreductase (STEAP3))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-STEAP3 Antibody

Binding Specificity: N-Term

Purpose: STEAP3 Antibody - N-terminal region

Sequence: LVGSGFKVVV GSRNPKRTAR LFPSAAQVTF QEEAVSSPEV IFVAVFREHY

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 92%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against STEAP3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STEAP3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8112922

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for STEAP3

Target: STEAP3 (STEAP Family Member 3, Metalloreductase (STEAP3))

Alternative Name: STEAP3

Background:

Background Information: AS an endosomal ferrireductase, STEAP3 is required for efficient transferrin-dependent iron uptake in erythroid cells. It participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+) and can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. STEAP3 uses NAD(+) as acceptor (By similarity). It may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. STEAP3 is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCT

Gene Name: STEAP family member 3, metalloreductase

Alternative Symbols: STMP3, TSAP6, pH yde, AHMIO2, dudlin-2, dudulin-2

Protein Name: Metalloreductase STEAP3

Molecular Weight: 54kDa

Gene ID: 55240

NCBI Accession: NP_001008410

UniProt: Q658P3

Pathways: Transition Metal Ion Homeostasis