HDAC4 antibody (C-Term)

Catalog No. ABIN2781487

The Rabbit Polyclonal anti-HDAC4 antibody has been validated for WB and ChIP. It is suitable to detect HDAC4 in samples from Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse and Saccharomyces cerevisiae.

Quick Overview for HDAC4 antibody (C-Term) (ABIN2781487)

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Product Details anti-HDAC4 Antibody

Binding Specificity: C-Term

Sequence: SSTVGHSLIE AQKCEKEEAE TVTAMASLSV GVKPAEKRSE EEPMEEEPPL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 77%, Human: 100%, Mouse: 86%, Rat: 93%, Yeast: 82%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against Hdac4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Hdac4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1076 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: Hdac4

Background: Hdac4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Alias Symbols: 4932408F19Rik, AI047285
Protein Interaction Partner: Rfxank, Mef2d, Mef2c, Mef2a, Dnajb6, Tnf, Runx2, Myocd, Ppp2ca, Gli2, Creb1, Atm, Ywhab, Ifrd1,
Protein Size: 1076

Molecular Weight: 118 kDa

Gene ID: 208727

NCBI Accession: NM_207225, NP_997108

UniProt: Q6NZM9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process