HDAC4 antibody (C-Term)

Catalog No. ABIN2781487

The Rabbit Polyclonal anti-HDAC4 antibody is suitable to detect HDAC4 in samples from Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse and Saccharomyces cerevisiae. It has been validated for WB and ChIP.

Quick Overview for HDAC4 antibody (C-Term) (ABIN2781487)

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Product Details anti-HDAC4 Antibody

Binding Specificity: C-Term

Purpose: Hdac4 Antibody - C-terminal region

Sequence: SSTVGHSLIE AQKCEKEEAE TVTAMASLSV GVKPAEKRSE EEPMEEEPPL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 77%, Human: 100%, Mouse: 86%, Rat: 93%, Yeast: 82%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against Hdac4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Hdac4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43602-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: Hdac4

Background:

Background Information: Hdac4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Alternative Symbols: HD4, 4932408F19Rik

Protein Name: Histone deacetylase 4

Molecular Weight: 118kDa

Gene ID: 208727

NCBI Accession: NP_997108

UniProt: Q6NZM9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process