ORCTL-2/SLC22A18 antibody (N-Term)

Catalog No. ABIN405596

The Rabbit Polyclonal anti-ORCTL-2/SLC22A18 antibody is suitable to detect ORCTL-2/SLC22A18 in samples from Human, Mouse, Rat, Cow, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for ORCTL-2/SLC22A18 antibody (N-Term) (ABIN405596)

Target: ORCTL-2/SLC22A18 (SLC22A18) (Solute Carrier Family 22 Member 18 (SLC22A18))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORCTL-2/SLC22A18 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ORCTL-2/SLC22A18 Antibody

Binding Specificity: N-Term

Purpose: SLC22A18 Antibody - N-terminal region

Sequence: AASSPALPGV YLLFASRLPG ALMHTLPAAQ MVITDLSAPE ERPAALGRLG

Predicted Reactivity: Cow: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SLC22A18. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC22A18

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43825-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ORCTL-2/SLC22A18

Target: ORCTL-2/SLC22A18 (SLC22A18) (Solute Carrier Family 22 Member 18 (SLC22A18))

Alternative Name: SLC22A18

Background:

Background Information: This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney.This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.

Gene Name: Solute carrier family 22, member 18

Alternative Symbols: HET, ITM, BWR1A, IMPT1, TSSC5, ORCTL2, BWSCR1A, SLC22A1L, p45-BWR1A

Protein Name: Solute carrier family 22 member 18

Molecular Weight: 45kDa

Gene ID: 5002

NCBI Accession: NP_002546

UniProt: Q96BI1