Slc6a14 antibody (Middle Region)

Catalog No. ABIN2781626

There are 2+ publications for this product available. The Rabbit Polyclonal anti-Slc6a14 antibody is suitable to detect Slc6a14 in samples from Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow and Guinea Pig. It has been validated for WB.

Quick Overview for Slc6a14 antibody (Middle Region) (ABIN2781626)

Target: Slc6a14 (Solute Carrier Family 6 (Amino Acid Transporter), Member 14 (Slc6a14))

Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Slc6a14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Slc6a14 Antibody

Binding Specificity: Middle Region

Purpose: SLC6A14 Antibody - middle region

Sequence: VFAGFAIFSI LGHMAHISGK EVSQVVKSGF DLAFIAYPEA LAQLPGGPFW

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SLC6A14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SLC6A14

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43925-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Slc6a14 antibody (ABIN2781626)

Coothankandaswamy, Cao, Xu, Prasad, Singh, Reynolds, Yang, Ogura, Ganapathy, Bhutia: "Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer." in: British journal of pharmacology, Vol. 173, Issue 23, pp. 3292-3306, (2016) (PubMed).

González, Martin, Burdsal, Sloan, Mager, Harris, Sutherland: "Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo." in: Developmental biology, Vol. 361, Issue 2, pp. 286-300, (2011) (PubMed).

Target Details for Slc6a14

Target: Slc6a14 (Solute Carrier Family 6 (Amino Acid Transporter), Member 14 (Slc6a14))

Alternative Name: SLC6A14

Background:

Background Information: This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a be

Gene Name: Solute carrier family 6 (amino acid transporter), member 14

Alternative Symbols: BMIQ11

Protein Name: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

Molecular Weight: 72kDa

Gene ID: 11254

NCBI Accession: NP_009162

UniProt: Q9UN76