NAT2 antibody (Middle Region)

Catalog No. ABIN2781757

Product Details anti-NAT2 Antibody

Target: NAT2 (N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAT2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE

Specificity: Antibody reacts with both NAT1 and NAT2

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against NAT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NAT2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 290 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NAT2 antibody (ABIN2781757)

Ricco, Cau, Marchand, Marty, Rodde-Dunet, Fender, Allemand, Corsini: "Stent-graft repair for thoracic aortic disease: results of an independent nationwide study in France from 1999 to 2001." in: The Journal of thoracic and cardiovascular surgery, Vol. 131, Issue 1, pp. 131-7, (2006) (PubMed).

Target Details for NAT2

Target: NAT2 (N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2))

Alternative Name: NAT2 (NAT2 Products)

Synonyms: AAC2 antibody, NAT-2 antibody, PNAT antibody, AV377607 antibody, Nat2a antibody, NAT antibody, AT-2 antibody, AT-B/AT-II antibody, AT-II antibody, AT2 antibody, N-acetyltransferase 2 antibody, N-acetyltransferase 2 (arylamine N-acetyltransferase) antibody, NAT2 antibody, Nat2 antibody

Background: NAT2 is a N-acetyltransferase 2 (arylamine N-acetyltransferase 2). This enzyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in its gene are reponsible for the N-acetylation polymorphism in which human populations segregate into rapid,intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity.This gene encodes N-acetyltransferase 2 (arylamine N-acetyltransferase 2). This enzyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are reponsible for the N-acetylation polymorphism in which human populations segregate into rapid,intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.
Alias Symbols: AAC2, PNAT
Protein Interaction Partner: APP, NAA10,
Protein Size: 290

Molecular Weight: 32 kDa

Gene ID: 10

NCBI Accession: NM_000015, NP_000006

UniProt: P11245