Butyrylcholinesterase antibody (N-Term)

Catalog No. ABIN2781762

This Rabbit Polyclonal antibody specifically detects Butyrylcholinesterase in WB and IHC. It exhibits reactivity toward Human, Mouse, Dog, Rat, Cow, Horse, Sheep, Guinea Pig, Pig and Rabbit.It has been mentioned in 1 publication

Quick Overview for Butyrylcholinesterase antibody (N-Term) (ABIN2781762)

Target: Butyrylcholinesterase (BCHE)

Reactivity: Human, Mouse, Dog, Rat, Cow, Horse, Sheep, Guinea Pig, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Butyrylcholinesterase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Butyrylcholinesterase Antibody

Binding Specificity: N-Term

Purpose: BCHE Antibody - N-terminal region

Sequence: SSLHVYDGKF LARVERVIVV SMNYRVGALG FLALPGNPEA PGNMGLFDQQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against BCHE. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BCHE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8095796

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Butyrylcholinesterase antibody (ABIN2781762)

Mizukami, Akatsu, Abrahamson, Mi, Ikonomovic: "Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease." in: Neuropathology : official journal of the Japanese Society of Neuropathology, Vol. 36, Issue 2, pp. 135-45, (2016) (PubMed).

Target Details for Butyrylcholinesterase

Target: Butyrylcholinesterase (BCHE)

Alternative Name: BCHE

Background:

Background Information: Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

Gene Name: Butyrylcholinesterase

Alternative Symbols: E1, CHE1, CHE2, BCHED

Protein Name: Cholinesterase

Molecular Weight: 68kDa

Gene ID: 590

NCBI Accession: NP_000046

UniProt: P06276

Pathways: Peptide Hormone Metabolism