TYR antibody (Middle Region)

Catalog No. ABIN2781791

The Rabbit Polyclonal anti-TYR antibody is suitable to detect TYR in samples from Human, Mouse, Rat, Pig, Dog, Cow, Goat, Horse, Sheep, Zebrafish (Danio rerio), Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for TYR antibody (Middle Region) (ABIN2781791)

Target: TYR (Tyrosinase (TYR))

Reactivity: Human, Mouse, Rat, Pig, Dog, Cow, Goat, Horse, Sheep, Zebrafish (Danio rerio), Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TYR Antibody

Binding Specificity: Middle Region

Purpose: TYR Antibody - middle region

Sequence: CLSLTQYESG SMDKAANFSF RNTLEGFASP LTGIADASQS SMHNALHIYM

Predicted Reactivity: Cow: 86%, Dog: 100%, Goat: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against TYR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TYR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8115083

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TYR

Target: TYR (Tyrosinase (TYR))

Alternative Name: TYR

Background:

Background Information: TYR is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. It catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

Gene Name: Tyrosinase (oculocutaneous albinism IA)

Alternative Symbols: ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3

Protein Name: Tyrosinase

Molecular Weight: 60 kDa

Gene ID: 7299

NCBI Accession: NP_000363

UniProt: P14679