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Thyroperoxidase antibody (N-Term)
TPO
Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Pig, Rabbit, Saccharomyces cerevisiae
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Thyroperoxidase Antibody
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Target
See all Thyroperoxidase (TPO) Antibodies
Thyroperoxidase (TPO)
(Thyroid Peroxidase (TPO))
Binding Specificity
All epitopes for Thyroperoxidase antibodies
N-Term
Reactivity
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Pig, Rabbit, Saccharomyces cerevisiae
Host
All hosts for Thyroperoxidase antibodies
Rabbit
Clonality
All clonalities for Thyroperoxidase antibodies
Polyclonal
Conjugate
All conjugates for Thyroperoxidase antibodies
This Thyroperoxidase antibody is un-conjugated
Application
All applications for Thyroperoxidase antibodies
Western Blotting (WB)
Sequence
GASNTALARW LPPVYEDGFS QPRGWNPGFL YNGFPLPPVR EVTRHVIQVS
Predicted Reactivity
Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 86%, Rat: 100%, Yeast: 83%
Characteristics
This is a rabbit polyclonal antibody against TPO. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human TPO
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for Thyroperoxidase
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Target
Thyroperoxidase (TPO)
(Thyroid Peroxidase (TPO))
Alternative Name
Thyroid Peroxidase (TPO Products )
Synonyms
MSA antibody, TDH2A antibody, TPX antibody, TPO antibody, msa antibody, tpx antibody, xtpo antibody, LOC100218312 antibody, thyroid peroxidase antibody, TPO antibody, Tpo antibody, tpo antibody, LOC100547103 antibody
Background
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. Protein Interaction Partner: DUOX1, TXNDC11, Protein Size: 611
Molecular Weight
67 kDa
Gene ID
7173
Pathways
Thyroid Hormone Synthesis
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