PPIB antibody (Middle Region)

Catalog No. ABIN2781832

The Rabbit Polyclonal anti-PPIB antibody (ABIN2781832) specifically detects PPIB in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio), Rabbit and Sheep samples.

Quick Overview for PPIB antibody (Middle Region) (ABIN2781832)

Target: PPIB (Cyclophilin B (PPIB))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio), Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPIB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PPIB Antibody

Binding Specificity: Middle Region

Purpose: PPIB Antibody - middle region

Sequence: FITTVKTAWL DGKHVVFGKV LEGMEVVRKV ESTKTDSRDK PLKDVIIADC

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%, Sheep: 86%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against PPIB. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PPIB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44365-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPIB

Target: PPIB (Cyclophilin B (PPIB))

Alternative Name: PPIB

Background:

Background Information: PPIB is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression.

Gene Name: Peptidylprolyl isomerase B (cyclophilin B)

Alternative Symbols: B, OI9, CYPB, SCYLP, CYP-S1, HEL-S-39

Protein Name: Peptidyl-prolyl cis-trans isomerase B

Molecular Weight: 24kDa

Gene ID: 5479

NCBI Accession: NP_000933

UniProt: A8K534