AGPAT2 antibody (C-Term)

Catalog No. ABIN2781951

The Rabbit Polyclonal anti-AGPAT2 antibody has been validated for WB. It is suitable to detect AGPAT2 in samples from Human and Pig.

Quick Overview for AGPAT2 antibody (C-Term) (ABIN2781951)

Target: AGPAT2 (1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2))

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGPAT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AGPAT2 Antibody

Binding Specificity: C-Term

Sequence: LEAIPTSGLT AADVPALVDT CHRAMRTTFL HISKTPQENG ATAGSGVQPA

Predicted Reactivity: Human: 100%, Pig: 91%

Characteristics: This is a rabbit polyclonal antibody against AGPAT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AGPAT2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 246 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AGPAT2

Target: AGPAT2 (1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2))

Alternative Name: AGPAT2

Background: AGPAT2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance.This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: 1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta
Protein Interaction Partner: ABCG8, PHRF1, PHF11, ANKRD28, SLC23A2, GMPS, UBC,
Protein Size: 246

Molecular Weight: 27 kDa

Gene ID: 10555

NCBI Accession: NM_001012727, NP_001012745

UniProt: Q5VUD3