CCDC90A antibody (Middle Region)

Catalog No. ABIN2782009

This Rabbit Polyclonal antibody specifically detects CCDC90A in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse and Guinea Pig. It has been mentioned in 4+ publications

Quick Overview for CCDC90A antibody (Middle Region) (ABIN2782009)

Target: CCDC90A (MCUR1) (Mitochondrial Calcium Uniporter Regulator 1 (MCUR1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC90A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CCDC90A Antibody

Binding Specificity: Middle Region

Purpose: CCDC90A Antibody - middle region

Sequence: ELHQLKQQVM DEVIKVRTDT KLDFNLEKSR VKELYSLNEK KLLELRTEIV

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CCDC90A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCDC90A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44777-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CCDC90A antibody (ABIN2782009)

Shanmughapriya, Rajan, Hoffman, Zhang, Guo, Kolesar, Hines, Ragheb, Jog, Caricchio, Baba, Zhou, Kaufman, Cheung, Kurosaki, Gill, Madesh: "Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU." in: Science signaling, Vol. 8, Issue 366, pp. ra23, (2015) (PubMed).

Mallilankaraman, Cárdenas, Doonan, Chandramoorthy, Irrinki, Golenár, Csordás, Madireddi, Yang, Müller, Miller, Kolesar, Molgó, Kaufman, Hajnóczky, Foskett, Madesh: "MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism." in: Nature cell biology, Vol. 14, Issue 12, pp. 1336-43, (2012) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, (2006) (PubMed).

Target Details for CCDC90A

Target: CCDC90A (MCUR1) (Mitochondrial Calcium Uniporter Regulator 1 (MCUR1))

Alternative Name: CCDC90A

Background:

Background Information: Essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Gene Name: Coiled-coil domain containing 90A

Alternative Symbols: FMP32, C6orf79, CCDC90A

Protein Name: Coiled-coil domain-containing protein 90A, mitochondrial

Molecular Weight: 40kDa

Gene ID: 63933

NCBI Accession: NP_001026883

UniProt: Q96AQ8