PARL antibody (N-Term)

Catalog No. ABIN2782038

The Rabbit Polyclonal anti-PARL antibody has been validated for WB and IHC. It is suitable to detect PARL in samples from Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow and Guinea Pig. There is 1 publication available.

Quick Overview for PARL antibody (N-Term) (ABIN2782038)

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PARL Antibody

Binding Specificity: N-Term

Sequence: SLIKPLFFTV GFTGCAFGSA AIWQYESLKS RVQSYFDGIK ADWLDSIRPQ

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%,

Characteristics: This is a rabbit polyclonal antibody against PARL. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PARL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 329 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PARL antibody (ABIN2782038)

Yoshioka, Katsu, Sakata, Okami, Wakai, Kinouchi, Chan: "The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 11, pp. 1658-65, (2013) (PubMed).

Target Details for PARL

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Alternative Name: PARL

Background: PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. PARL may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in its gene has been associated with increased risk for type 2 diabetes.This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Protein Interaction Partner: UBC, PINK1,
Protein Size: 329

Molecular Weight: 36 kDa

Gene ID: 55486

NCBI Accession: NM_001037639, NP_001032728

Pathways: Autophagy