Cadherin 4 antibody (N-Term)

Catalog No. ABIN2782139

The Rabbit Polyclonal anti-Cadherin 4 antibody is suitable to detect Cadherin 4 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for Cadherin 4 antibody (N-Term) (ABIN2782139)

Target: Cadherin 4 (CDH4)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cadherin 4 Antibody

Binding Specificity: N-Term

Purpose: CDH4 Antibody - N-terminal region

Sequence: ENSRGPFPQQ LVRIRSDKDN DIPIRYSITG VGADQPPMEV FSIDSMSGRM

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CDH4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CDH4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45172-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Cadherin 4

Target: Cadherin 4 (CDH4)

Alternative Name: CDH4

Background:

Background Information: CDH4 gene is a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Cadherin 4, type 1, R-cadherin (retinal)

Alternative Symbols: CAD4, RCAD, R-CAD

Protein Name: Cadherin-4

Molecular Weight: 82kDa

Gene ID: 1002

NCBI Accession: NP_001785

UniProt: P55283

Pathways: Cell-Cell Junction Organization, Regulation of Cell Size