GZMK antibody (N-Term)

Catalog No. ABIN2782156

The Rabbit Polyclonal anti-GZMK antibody is suitable to detect GZMK in samples from Human, Pig and Horse. It has been validated for WB.

Quick Overview for GZMK antibody (N-Term) (ABIN2782156)

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Reactivity: Human, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GZMK Antibody

Binding Specificity: N-Term

Purpose: GZMK Antibody - N-terminal region

Sequence: PTVVLGAHSL SKNEASKQTL EIKKFIPFSR VTSDPQSNDI MLVKLQTAAK

Predicted Reactivity: Horse: 79%, Human: 100%, Pig: 86%

Characteristics: This is a rabbit polyclonal antibody against GZMK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GZMK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8101902

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GZMK

Target: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Alternative Name: GZMK

Background:

Background Information: GZMK is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.

Gene Name: Granzyme K (granzyme 3, tryptase II)

Alternative Symbols: TRYP2

Protein Name: Granzyme K

Molecular Weight: 26kDa

Gene ID: 3003

NCBI Accession: NP_002095

UniProt: P49863